2024

1. Oxidative Coupling of Hydroquinone Derivatives with Olefins to Dihydrobenzofurans  
   Yoshinari Sawama, Keiichiro Nakajima, Takaaki Aijima, Miyu Mae, Shinsuke Komagawa, Hiroki Nakata, Hironao Sajiki, and Shuji Akai  
   Chem. Pharm. Bull.,  2024, 72, 566-569.

2. Stable and Versatile Pd Precursors for the Preparation of Robust Pd Catalysts under Continuous-Flow
   Naoya Sakurada, Kwihwan Kobayashi, Yuka Abe, Kosuke Niwa, Takashi Yokoyama, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki
   ChemSusChem, e202401859
   https://doi.org/10.1002/cssc.202401859
   
   
   
3. Pt/CB-Catalyzed Chemoselective Hydrogenation Using In Situ-Generated Hydrogen by Microwave-Mediated Dehydrogenation of Methylcyclohexane under Continuous-Flow Conditions
   Naoya Sakurada ,Takanori Kitazono, Takashi Ikawa, Tsuyoshi Yamada and Hironao Sajiki
   Catalysts, 2024, 14, 384 (Open Access).
   https://doi.org/10.3390/catal14060384
   
   
   
4. Gold-Catalyzed Synthesis of Ortho-Quinone Methide Analogues as Reactive Synthetic Precursors
   Tsuyoshi Yamada, Akiko Fujii, Chikara Furugen, Kwihwan Kobayashi, Tomoki Hyodo, Takashi Ikawa, Hironao Sajiki
   Adv. Synth. Catal., 2024, 366, 2270‐2276.
   DOI: https://doi.org/10.1002/adsc.202400013
   Hot Topics!
   https://chemistry-europe.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1521-3765.hottopic-gold
   
   　　
5. Versatile Biaryls and Fused Aromatics through Oxidative Coupling of Hydroquinones with (Hetero)Arenes
   Takaaki Aijima, Rina Ueda, Takanori Nakane, Fumiaki Makino, Yusuke Ohnishi, Jin Tokunaga, Keiichiro Nakajima, Shinichiro Kamino, Genji Kurisu, Keiichi Namba, Hiroki Nakata, Kaiki Mogi, Hironao Sajiki, Shuji Akai, Yoshinari Sawama
   ChemistrySelect, 2024, e202400647.
   https://doi.org/10.1002/slct.202400647
   
   
   
6. First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls
   M. Ishida, R. Adachi, K. Kobayashi, Y. Yamamoto, C. Kawahara, T. Yamada, H. Aoyama, K. Kanomata, S. Akai, P. Y. S. Lam, H. Sajiki, T. Ikawa
   Chem. Commun. 2024, 60, 678-681.
   DOI：10.1039/d3cc05447k
   
   
   

2023

1. Multiple Deuteration of Triphenylphosphine and Live-Cell Raman Imaging of Deuterium-incorporated Mito-Q
   Shogo Moriyama, Miyu Mae, Daiki Shibata, Hiroyuki Yamakoshi, Shinji Kajimoto, Takakazu Nakabayashi, Takayoshi Ishimoto, Kaiki Mogi, Hironao Sajiki, Shuji Akai, Yoshinari Sawama
   Chem. Commun. 2023, 59, 12100-12103.
   DOI https://doi.org/10.1039/D3CC04410F
   
   
   
2. Oxidative Functionalization of Catechol Derivatives Substituted with Electron-withdrawing Groups
   Yoshinari Sawama Hyoga Shimizu, Takaaki Aijima, Taro Udagawa, Shoko Kuwata, Tsuyoshi Yamada, Hironao Sajiki, and Shuji Akai
   Chem. Pharm. Bull. 2023, 71, 782-786.
   https://doi.org/10.1248/cpb.c23-00493
   
   
   
3. Impact of Multiple H/D Replacement on the Physicochemical Properties of Flurbiprofen
   Hiromasa Uchiyama, Kazuho Ban, Shiho Nozaki, Yui Ikeda, Takayoshi Ishimoto, Hiroyoshi Fujioka, Mako Kamiya, Ryugo Amari, Hirofumi Tsujino, Masayoshi Arai, Sachi Yamazoe, Keiko Maekawa, Takuma Kato, Mitsunobu Doi, Kazunori Kadota, Yuichi Tozuka, Naohito Tomita, Hironao Sajiki, Shuji Akai, Yoshinari Sawama
   RSC Med. Chem. 2023, 14, 2583-2592.
   DOI: 10.1039/d3md00357d
   
   
   
4. Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D3 Derivatives with Structure–Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs
   Kazuki Maekawa, Michiyasu Ishizawa, Takashi Ikawa, Hironao Sajiki, Taro Matsumoto, Hiroaki Tokiwa, Makoto Makishima and Sachiko Yamada
   Biomolecules 2023, 13, 1082. 　
   https://doi.org/10.3390/biom13071082
   https://www.mdpi.com/2218-273X/13/7/1082/pdf
   Open Access!
   
   
   
5. Microwave-assisted C–C bond formation of diarylacetylenes and aromatic hydrocarbons on carbon beads under continuous-flow conditions
   Tsuyoshi Yamada, Wataru Teranishi, Naoya Sakurada, Seiya Ootori, Yuka Abe, Tomohiro Matsuo, Yasuharu Morii, Masatoshi Yoshimura, Takeo Yoshimura, Takashi Ikawa and Hironao Sajiki
   Commun. Chem. 2023, 6,78
   
   DOI: https://doi.org/10.1038/s42004-023-00880-y　
   Synfacts 2023; 19: 0848
   Open Access!
   
   
   
6. Homemade Solution of NaOD in D₂O: Applications in the Field of Stilbene-d1 Synthesis
   Keisuke Imai, Naohito Tomita, Hiroyoshi Fujioka, Mako Kamiya, Riku Ogasahara, Kazuho Ban, Hyoga Shimizu, Takayoshi Ishimoto, Hironao Sajiki, Shuji Akai, Yoshinari Sawama
   Asian J. Org. Chem., 2023, 12, e202200690
   https://doi.org/10.1002/ajoc.202200690
   
   
   
7. Unprecedented Regioselective Deuterium-Incorporation of Alkyltrimethylammonium Chlorides and Raman Analysis
   Yoshinari Sawama, Takumi Matsuda, Shogo Moriyama, Kazuho Ban, Hiroyoshi Fujioka, Mako Kamiya, Jingwen Shou, Yasuyuki Ozeki, Shuji Akai, Hironao Sajiki
   Asian J. Org. Chem., 2023, 12, e202200710
   https://doi.org/10.1002/ajoc.202200710
   

2022

1. Development of Silicon Carbide-Supported Palladium Cata-lysts and Their Application as Semihydrogenation Catalysts for Alkynes under Batch- and Continuous-Flow Conditions
   Tsuyoshi Yamada, Haruka Yamamoto, Kanon Kawai, Kwihwan Park, Norihiko Aono and Hironao Sajiki
   Catalysts 2022, 12(10), 1253
   https://doi.org/10.3390/catal12101253
   
   
   
2. Highly Selective Synthesis of cis-2,2,4,4-Tetramethylcyclobutane-1,3-diol via Solvent-Free Hydrogenation and Isomerization
   Kwihwan Park, Shinichi Furusato, Chikara Furugen, Takashi Ikawa, Tsuyoshi Yamada, and Hironao Sajiki
   Asian J. Org. Chem. 2022, 11, e202200263.
   http://dx.doi.org/10.1002/ajoc.202200263.
   
   
   
3. Heavy water recycling for producing deuterium compounds
   Kazuhiro Akutsu-Suyama, Hironao Sajiki,b Misaki Ueda,a Makiko Asamotoc and Yasuyuki Tsutsumi
   RSC Advances 2022, 12, 24821-24829.
   DOI: 10.1039/D2RA04369F
   
4. Catalytic Intramolecular Cyclization of Alkynyl Cyclic Acetals via Chemoselective Activation Leading to Phenanthrene Core
   Tsuyoshi Yamada, Akiko Fujii, Kwihwan Park, Chikara Furugen, Akira Takagi, Takashi Ikawa, and Hironao Sajiki
   Bull. Chem. Soc. Jpn., 2022, 95 735-742
   doi:10.1246/bcsj.20220036
   
5. Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki–Miyaura Coupling Conditions
   Naoki Oka, Tsuyoshi Yamada, Hironao Sajiki, Shuji Akai, Takashi Ikawa
   Org. Lett. 2022 24, 19, 3510-3514.
   https://doi.org/10.1021/acs.orglett.2c01174
   Synfacts 2022; 18(08): 0867
   DOI: 10.1055/s-0041-1738238
   
   
   
   

   Most Read Articles https://pubs.acs.org/action/showMostReadArticles?journalCode=orlef7

   

   
   
   
   
   
6. Highly Selective Hydrogenative Conversion to the Tertiary, Secondary, and Primary Amines of Nitriles under Flow Reaction Conditions
   Tsuyoshi Yamada,Kwihwan Park, Chikara Furugen, Jing Jiang, Eisho Shimizu, Naoya Ito, and Hironao Sajiki
   ChemSusChem 2022, 15, e202102138.
   https://doi.org/10.1002/cssc.202102138
   Synfacts 2022; 18(02): 0225
   DOI: 10.1055/s-0041-1737512
   
   
   
7. Platinum on Carbon-Catalysed Site-Selective H-D Exchange Reaction of Allylic Alcohols Using Alkyl Amines as a Hydrogen Source
   Kwihwan Park, Naoki Oka, Yoshinari Sawama, Takashi Ikawa, Tsuyoshi Yamada, Hironao Sajiki
   Org. Chem. Front. 2022, 9, 1986 - 1991.
   DOI: 10.1039/D2QO00177B.
   
   
   
8. Multicomponent Double Mannich Alkylamination Involving C(sp2 )–H and Benzylic C(sp3 1 )–H Bonds
   Zhencheng Lai, Rongkai Wu, Jiaming Li, Xing Chen, Linwei Zeng, Xi Wang, Jingjing Guo, Zujin Zhao, Hironao Sajiki, and Sunliang Cui*
   Nature Commun., 2022, 13:435.
   doi.org/10.1038/s41467-022-28088-z
   
   

2021

1. Esterification or thioesterification of carboxylic acids with alcohols or thiols using amphipathic monolith-SO3H resin
   Fumika Wakayama, Ryo Ito, Kwihwan Park, Moeka Ishida, Yutaro Yamada, Shuta Ichihara, Hitoshi Takada, Shinji Nakamura, Ayumu Kato, Tsuyoshi Yamada, Hironao Sajiki,* and Yasunari Monguchi*
   Bull. Chem. Soc. Jpn.,?2021,?94, 2702-2710.
   doi:10.1246/bcsj.20210266
   Highlighted in SYNFACTS 2022, 18, 418.
   DOI: 10.1055/s-0041-1737376
   
   
2. Ruthenium-on-Carbon-Catalyzed Facile Solvent-Free Oxidation of Alcohols: Efficient Progress under Solid-Solid (Liquid)-Gas Conditions
   Kwihwan Park, Jing Jiang, Tsuyoshi Yamada, and Hironao Sajiki
   Chem. Pharm. Bull. 2021, 69, 1200–1205
   https://doi.org/10.1248/cpb.c21-00749
   
   
   
3. Gold-Catalyzed Tandem Oxidative Coupling Reaction between β-Ketoallenes and Electron-Rich Arenes to 2-Furylmethylarenes
   Naoki Yasukawa, Yutaro Yamada, Chikara Furugen, Yuya Miki,Hironao Sajiki, Yoshinari Sawama
   Org. Lett., 2021, 23, 15, 5891–5895
   DOI: 10.1021/acs.orglett.1c02007
   
   
   
4. Could London Dispersion Force Control Regioselective (2+2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes Helicene
   Takashi Ikawa,* Yuta Kenzo Yahat, Yamamoto, Akito Heguri, Yutaka Fukumoto, Tomonari Murakami, Akira Takagi, Yuto Masuda, Kenzo Yahata, Kenzo Yahata, Hiroshi Aoyama, Yasuteru Shigeta, Hiroaki Tokiwa,* Shuji Akai*
   J. Am. Chem. Soc. 2021, 143, 10853?10859.
   DOI: 10.1021/jacs.1c05434.
   Highlighted in SYNFACTS 2021,?17, 0981
   DOI: 10.1055/s-0040-1720812
   
   　
   
   
   
5. Synthesis of 1-Pyrroline by Denitrogenative Ring Expansion of Cyclobutyl Azides under Thermal Conditions
   Yuya Miki, Naohito Tomita, Kazuho Ban, Hironao Sajiki,Yoshinari Sawama
   Adv. Synth. Catal. 2021, 363, 3481– 3484.
   DOI: 10.1002/adsc.202100329
   
   
   
   
6. Palladium on Carbon–Catalyzed Oxidative Transformation of Benzylic Ethers
   Ryoya Takakura, Shoko Kuwata, Kouki Nakano, Naoki Yasukawa, Hironao Sajiki,* and Yoshinari Sawama*
   HETEROCYCLES, 2021, 103, 494-501
   (Special Issue Vol. 103 in honor of Professor Yasuyuki Kita on 77th Birthday)
   DOI : 10.3987/COM-20-S(K)25
   
   
   
7. Efficient Continuous-Flow H-D Exchange Reaction of Aromatic Nuclei in D₂O/2-PrOH Mixed Solvent in Catalysts Cartridge Packed with Platinum on Carbon Beads
   Kwihwan Park, Naoya Ito, Tsuyoshi Yamada, and Hironao Sajiki
   Bull. Chem. Soc. Jpn. 2021, 94, 600-605.
   Selected Paper
   
8. Revisiting the Synthesis of Aryl Nitriles: a Pivotal Role of CAN
   Rakhee Saikia, Kwihwan Park, Hayato Masuda, Miki Itoh, Tsuyoshi Yamada, Hironao Sajiki, Sanjeev P. Mahanta, Ashim J. Thakur, Utpal Bora
   Org. Biomol. Chem. 2021, 19, 1344-51
   https://doi.org/10.1039/D0OB02518F
   
   

2020

1. Copper-Catalyzed Aqueous N–O Bond Cleavage of 2-Oxa-3-Azabicyclo Compounds to Cyclic cis-1,4-Amino Alcohols
   Naoki Yasukawa, Yuya Miki, Marina Kuwata, Hironao Sajiki* and Yoshinari Sawama*
   ChemSusChem, 2020, 13, 5632-5637.
   https://doi.org/10.1246/bcsj.20200325
   　　　
   
   
2. Skeletal Reorganization Divergence of N-Sulfonyl Ynamides
   Linwei Zeng, Yuxin Lin, Jiaming Li, Hironao Sajiki, Hujun Xie, Sunliang Cui
   Nature Commun. 2020, 11, 5639-5648. Open Access
   https://doi.org/10.1038/s41467-020-19467-5
   
   
   
3. Improvement Parameters in Hydrogen Generation from Water under Stainless-steel-Mediated Ball Milling Conditions
   Miki Itoh, Yoshinari Sawama,* Miki Niikawa, Kazuho Ban, Takahiro Kawajiri, and Hironao Sajiki*
   Bull. Chem. Soc. Jpn., 2020, 93, 1366-1371.
   doi:10.1246/bcsj.20200179 
   
   
   
4. One-pot Heteroarene Synthesis Based on Ruthenium-on-Carbon-Catalyzed Oxidative Aromatization using Oxygen
   Yuta Yamamoto, Yutaro Yamada, Hironao Sajiki* and Yoshinari Sawama*
   Bull. Chem. Soc. Jpn., 2020, 93, 1419-1423.
   doi:10.1246/bcsj.20200155  
   
   
   
5. Pd catalysts supported on dual-pore monolithic silica beads for chemoselective hydrogenation under batch and continuous-flow reaction conditions
   Tsuyoshi Yamada, Aya Ogawa, Hayato Masuda, Wataru Teranishi, Akiko Fujii, Kwihwan Park, Yosuke Ashikari, Noriyuki Tomiyasu, Tomohiro Ichikawa, Riichi Miyamoto, Hongzhi Bai, Kiyoshi Matsuyama, Aiichiro Nagaki, and Hironao Sajiki*
   Catal. Sci. Technol. 2020, 10, 6359-6367
   DOI: 10.1039/D0CY01442G
   
   
   
6. Development of a Facile and Simple Processes for Heterogeneous Pd-Catalyzed Ligand–Free Continuous-Flow Suzuki–Miyaura Coupling
   Tsuyoshi Yamada, Jing Jiang, Naoya Ito, Kwihwan Park, Hayato Masuda, Chikara Furugen, Moeka Ishida, Seiya ?tori, Hironao Sajiki
   Catalysts, 2020, 10, 1209-1222.
   doi:10.3390/catal10101209
   
   
   
7. Hydroquinone and Benzoquinone-Catalyzed Aqueous Knoevenagel Condensation
   Ryoya Takakura, Kaho Koyama, Marina Kuwata, Tsuyoshi Yamada, Hironao Sajiki* and Yoshinari Sawama*
   Org. Biomol. Chem., 2020, 18, 6594-6597.
   DOI: 10.1039/d0ob01397h
   
   
   
8. Quantitative Mechanochemical Methanation of CO₂ with H₂O in a Stainless Steel Ball Mill
   Yoshinari Sawama*, Miki Niikawa, Kazuho Ban, Kwihwan Park, Shin-yo Aibara, Miki Itoh, and Hironao Sajiki*
   Bull.,Chem., Soc., Jpn.. 2020, 93, 1074-1078.
   
   
   
9. Development of Carbon-Neutral Cellulose-Supported Heterogeneous Palladium Catalysts for Chemoselective Hydrogenation

   Tsuyoshi Yamada, Wataru Teranishi, Kwihwan Park, Jing Jiang, Takumu Tachikawa, Shinichi Furusato, and Hironao Sajiki

   ChemCatChem, 2020, 12, 4052–4058.

   https://doi.org/10.1002/cctc.202000805
   Hot Topics Hot Topic: Carbon, Graphite, and Graphene
   Twitter: https://twitter.com/ChemCatChem/status/1281483956752396288
   
10. Robust Continuous-Flow Synthesis of Deuterium-Labeled β-Nitroalcohols Catalyzed by Basic Anion Exchange Resin
    Tsuyoshi Yamada, Kwihwan Park, Naoya Ito, Hayato Masuda, Wataru Teranishi, Sunliang Cui, Hironao Sajiki
    Bull. Chem. Soc. Jpn. 2020, 93, 1000-1006.
    https://doi.org/10.1246/bcsj.20200067
    Selected as SP(Selected Paper)!
    
    
    
    
11. Preparation of N2-Ethyl-2'-deoxyguanosine-d4 as an Internal Standard for the Electrospray Ionization-Tandem Mass Spectrometric (ESI-MS/MS) Determination of DNA Damage by Acetaldehyde.
    Esaka Y, Aruga H, Kunishima S, Yamamoto T, Murakami H, Sawama Y, Sajiki H, Uno B.
    Anal., Sci., 2020, 36, 877-880 
    https://doi.org/10.2116/analsci.19N034
    
    
    
12. Arylation of Indoles Using Cyclohexanones Dually-Catalyzed by Niobic Acid and Palladium-on-Carbons
    Kazuho Ban, Yuta Yamamoto, Hironao Sajiki,* Yoshinari Sawama*
    Org. Biomol. Chem., 2020,18, 3898-3902
    https://doi.org/10.1039/D0OB00702A
    
13. Practical and reliable synthesis of 2′,3′,5′,5′′-tetradeuterated uridine derivatives
    Noriko Miyamoto, Hiroki Ohno, Yoshiaki Kitamura, Kwihwan Park, Yoshinari Sawama, Hironao Sajiki & Yukio Kitade
    Nucleosides, Nucleotides & Nucleic Acids, 2020, 39, 236-244
    https://doi.org/10.1080/15257770.2019.1669170
    
14. N-Heterocyclic carbene-catalyzed deuteration of aldehydes in D₂O
    Yoshinari Sawama*, Yuya Miki, Hironao Sajiki*
    Synlett, 2020, 31, 699-702
    DOI: 10.1055/s-0040-1707993
    
15. Gold-Catalyzed Cyclization of 2-Alkynylaldehyde Cyclic Acetals via Hy-dride Shift for the Synthesis of Indenone Derivatives
    Tsuyoshi Yamada, Kwihwan Park, Takumu Tachikawa, Akiko Fujii, Matthias Rudolph, A. Stephen K. Hashmi, and Hironao Sajiki
    Org. Lett. 2020, 22, 1883-1888
    https://doi.org/10.1021/acs.orglett.0c00221
    
16. Facile Hydrogenative Deprotection of N-Benzyl Groups Using a Mixed Catalyst of Palladium and Niobic Acid on Carbon
    Yamamoto, Yuta; Shimizu, Eisho; Ban, Kazuho; Wada, Yoshiyuki; Mizusaki, Tomoteru; Yoshimura, Masatoshi; Takagi, Yukio; Sawama, Yoshinari; Sajiki, Hironao
    ACS Omega, 2020, 5, 2699−2709
    DOI: 10.1021/acsomega.9b03226
    
    
    
    
17. PLATINUM ON CARBON–CATALYZED AND CHEMOSELECTIVE AQUEOUS OXYGEN OXIDATION OF AROMATIC ACETALS TO BENZOIC ACIDS
    Naoki Yasukawa, Takumi Matsuda, Eisho Shimizu, Hironao Sajiki, Yoshinari Sawama
    Heterocycles, 2020, 100, 145-152
    DOI: 10.3987/COM-19-14122 Open Access!!